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Entertainment

7 Long-Running TV Shows That Replaced Their Lead Actor

By Matthias Binder November 5, 2026
7 Long-Running TV Shows That Replaced Their Lead Actor
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Most viewers expect a series star to stay put until the final episode. Television doesn’t always work that way. Contract fights, health problems, creative changes and plain career choices have all pushed leads out of shows that kept going.

Contents
Doctor WhoBewitchedMission: ImpossibleThe Dukes of HazzardTwo and a Half MenMidsomer MurdersCSI: Crime Scene Investigation

Some of these swaps were planned from the start, while others were messy and public. Here are seven well-known series that carried on with a new face at the center.

Doctor Who

Doctor Who (Image Credits: Unsplash)
Doctor Who (Image Credits: Unsplash)

This is the textbook case. When William Hartnell’s health declined, the BBC wrote the change into the story in 1966. The Doctor “regenerated” into Patrick Troughton, and the idea gave the show a way to recast its lead again and again.

The habit has lasted for decades. Ncuti Gatwa took over the role in the 2023 Christmas special, and his first full season aired in 2024. Casting changes are a built in feature of the series, which helps explain why it has survived for so long.

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Bewitched

Bewitched (Image Credits: Pixabay)
Bewitched (Image Credits: Pixabay)

Dick York played Darrin Stephens, the mortal husband of Samantha, for the first five seasons. He left after those seasons because of health problems tied to a back injury. Dick Sargent took over the role from season six, which began in 1969.

The show offered no explanation on screen. Darrin simply looked different, and the comedy kept going. Fans still debate which actor did it better, a sign of how closely the role is tied to both men.

Mission: Impossible

Mission: Impossible (Image Credits: Wikimedia)
Mission: Impossible (Image Credits: Wikimedia)

The original series began in 1966 with Steven Hill as Dan Briggs, the leader of the Impossible Missions Force. After the first season, the producers made a change at the top. Peter Graves arrived as Jim Phelps, who led the team for most of the series.

The switch is easy to miss now because Phelps became the definitive leader. His name was carried into later versions of the franchise, including the 1988 revival and the first Tom Cruise film. The first season lead is now largely a footnote.

The Dukes of Hazzard

The Dukes of Hazzard (Image Credits: Pexels)
The Dukes of Hazzard (Image Credits: Pexels)

This one was brief, but it was memorable. In 1982, Tom Wopat and John Schneider, who played Luke and Bo Duke, left the show during a contract dispute. Byron Cherry and Christopher Mayer were brought in as their cousins Coy and Vance.

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The replacements didn’t catch on with audiences. Wopat and Schneider returned later in the same season after the dispute was settled. It stands as an unusually quick reversal in television casting.

Two and a Half Men

Two and a Half Men (Image Credits: Pexels)
Two and a Half Men (Image Credits: Pexels)

Charlie Sheen was the biggest name on the sitcom, playing Charlie Harper. Production halted in early 2011 after a very public falling out with the network and producers, and Sheen was fired. Ashton Kutcher joined as a new character, Walden Schmidt, a tech millionaire who buys the house.

Charlie’s absence was handled with a dark joke at the start of the new season. The show continued for several more seasons with Kutcher and ended in 2015 after twelve seasons. Few lead replacements have drawn this much press attention.

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Midsomer Murders

Midsomer Murders (Image Credits: Pexels)
Midsomer Murders (Image Credits: Pexels)

John Nettles played Detective Chief Inspector Tom Barnaby for well over a decade. He left the British crime drama in 2011 after thirteen seasons. Neil Dudgeon stepped in as DCI John Barnaby, introduced as Tom’s cousin.

The setup kept the family name and the quiet village setting that viewers liked. The series carried on for many years after the handover. It shows that a strong format can outlast the actor who first defined it.

CSI: Crime Scene Investigation

CSI: Crime Scene Investigation (Image Credits: Unsplash)
CSI: Crime Scene Investigation (Image Credits: Unsplash)

William Petersen anchored the original CSI as Gil Grissom through its early seasons. He stepped away during the ninth season, around 2008 and 2009. Laurence Fishburne then joined the cast as Dr. Raymond Langston, a former medical examiner turned investigator.

Another change came in 2011, when Ted Danson joined as D.B. Russell, the new head of the night shift. The series ran for fifteen seasons in total. Its willingness to keep refreshing the leadership helped it last.

Previous Article 9 TV Shows Canceled After One Season That Built Cult Followings 9 TV Shows Canceled After One Season That Built Cult Followings
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